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News

DunedinPACE and brain structure

February 3, 2024

DunedinPACE
LoNG graduate student Ethan Whitman describes associations between DunedinPACE, a novel epigenetic measure of biological aging, and measures of brain structure. Importantly, the associations replicate in three independent cohorts.

Reliability of the principal FC gradient

October 20, 2023

gradientReliability
LoNG Research Associate Annchen Knodt evaluates test-retest reliability of principal FC gradient measures, finding good reliability as well as associations with aging and cognition.

Self-regulation and macroscrale brain organization

August 31, 2023

selfRegulation
Professor Hariri, along with Professor Tim Strauman, discusses how examination of intrinsic macroscale brain organization, as reflected in the principal FC gradient, can extend and enrich investigations of self-regulation and depression.

Topography predicts cognitive & motor abilities

June 20, 2023

topography
LoNG graduate student Ethan Whitman examines cortical functional topography using fMRI in the Dunedin Study, finding associations with IQ and gait speed.

Long-term cannabis use and brain structure

August 23, 2022

cannabisLoNG research associate Annchen Knodt presents findings of reduced structural brain integrity in members of the Dunedin Study with a long history of cannabis use, but patterns are explained by their propensity to use other substances as well.

The subcortex and antisocial behavior

October 18, 2021

antisocialSCCheck out the latest from LoNG collaborator Christina Carlisi on the structural brain correlates of lifecourse-persistent antisocial behavior, this time looking at subcortical volumes, published in Development and Psychopathology.

Striving towards translation

June 14, 2021

TiCS_reliabilityWe've demonstrated that commonly used task fMRI measures are not reliable enough for individual differences research or clinical translation. Our latest Trends in Cognitive Sciences review focuses on what we can do to work towards generating fMRI measures that are.

Neural embedding of childhood adversity

Mar 9, 2021

ACEsLoNG graduate student Maria Gehred explores links between prospective and retrospective measures of childhood maltreatment and structural brain integrity at midlife.

Fitness and white matter

Apr 6, 2021

leadTo aid efforts to identify early life interventions for mitigating risk for dementia, LoNG graduate student Tracy d'Arbeloff explores possible links between white matter integrity and fitness and healthy lifestyle behaviors in midlife.

Pace of aging

Mar 15, 2021

leadLoNG graduate student Max Elliott reports on disparities in the pace of aging at midlife. This study is made possible by the efforts of many individuals over many years to collect high quality measures of 19 biomarkers indexing the cardiovascular, metabolic, renal, immune, detal, and pulmonary systems in Dunedin Study members across adulthood and into midlife. Check it out in Nature Aging!

Self-control and preparedness for old age

Jan 19, 2021

leadLoNG collaborator Dr. Leah Richmond-Rakerd demonstrates that as adults, children with better self-control aged more slowly, showed fewer signs of brain aging, and were more equipped to manage later-life health, financial, and social demands.

Childhood lead exposure, brain, and cognitive decline

Nov 17, 2020

leadThis week in JAMA, LoNG and colleagues report associations between childhood lead exposure and mid-life measures of brain integrity, as well as cognitive decline. Read about the study in Duke Today or check out the report in JAMA.

Transdiagnostic cortical thinning

July 3, 2020

p_cortexNow published in AJP: cortical thinning is a transdiagnostic feature of general psychopathology. Also check out the editor's spotlight on the article!

The (un)reliability of task-fMRI

June 3, 2020

conductDisorderA new LoNG study published in Psychological Science points to the unreliability of task-fMRI, and its unsuitability for individual differences research. Read more on APS News or Duke Today.

Hidden Links

May 5, 2020

conductDisorderNature News discusses ongoing efforts to understand general psychopathology, including work by the LoNG.

Long-term offenders have different brain structure

February 17, 2020

conductDisorderA study led by LoNG collaborator Christina Carlisi finds associations between life-course-persistent antisocial behavior and cortical surface area and thickness. Read more about it on BBC News or The Guardian.

Brain-age in midlife

December 10, 2019

brain-ageLearn more about brain-age from our study published in Molecular Psychiatry.

White Matter Hyperintensities

December 9, 2019

WMHPublished in Brain Communications: white matter hyperintensities are present in mid-life, and already predict cognitive decline.

Replication study

December 3, 2019

pReplicationPublished in Molecular Psychiatry: replicability of structural brain alterations associated with general psychopathology.

Gait speed and the brain

October 2, 2019

gaitLearn more about gait speed from our study published in JAMA.

Commentary in Neuron

April 4, 2019

spitCheck out Dr. Hariri's commentary in Neuron, "The emerging importance of the cerebellum in broad risk for psychopathology."

General Functional Connectivity

February 5, 2019

spitCheck out the latest publication by LoNG grad student Max Elliott, demonstrating how shared features of resting-state and task fMRI drive reliable and heritable individual differences in functional brain networks.

Spit

November 1, 2018

spit Check out iHeartRadio and 23andMe's new podcast about the cultural influences of DNA testing.

Duke Magazine

September 14, 2018

AdrienneDefense In the Duke Magazine special issue on fear, Professor Hariri comments on fear and the brain.

Congrats!

May 29, 2018

AdrienneDefense Congrats to grad student Adrienne Romer on her successful PhD defense!

Mental illness risk and the connectome

May 1, 2018

audible_wwytLoNG grad student Max Elliott finds that transdiagnostic risk for mental illness maps onto hyper-connectivity between visual association cortex and networks supporting executive control and self-referential processes. Read about it in Duke Today, New England Journal of Medicine's Psychiatry Watch, The Chronicle, or check out the full paper or commentary in Biological Pyschiatry.

Congrats!

March 21, 2018

MattDefense Congrats to grad student Matt Scult on his successful PhD defense!

What Were You Thinking?

January 12, 2018

audible_wwyt Episode 5: "You're Not Alone" of the Audible original podcast What Were You Thinking features commentary from Professor Hariri on how changes in the adolescent brain can lead to violence. Check it out!

Prefrontal Cortex Buffers Against Anxiety

November 17, 2017

3way_PFCbuffer Head over to Duke Today, Forbes, Psychology Today, or The Herald Sun to read about LoNG grad student Matt Scult's work published today in Cerebral Cortex.

Outsmarting Our Primitive Responses to Fear

October 26, 2017

NYT A New York Times article features Professor Hariri's research into the amygdala.

Insomnia-related depression and the brain

September 14, 2017

VS_sleep_dep LoNG postdoc Reut Avinun finds that increased reward-related ventral striatum activity is associated with a weaker link between sleep disturbances and depression in the DNS. Read more in Duke Today, Express, or Live Science.

Corticolimbic connectivity and anxiety

September 8, 2017

Kim_SciRep LoNG postdoc Justin Kim shows that a link between corticolimbic structrual connectivity and trait anxiety is influenced by BDNF genotype and sex.

Dr. Kim!

June 13, 2017

JustinGrad LoNG postdoc Justin Kim celebrates his graduation from Dartmouth with advisor Dr. Paul Whalen!

Congrats!

April 20, 2017

AdrienneAPS LoNG graduate student Adrienne Romer is awarded the Association for Psychological Science's Student Research Award!

General risk for mental illness

April 11, 2017

p_cerebellum The LoNG links structural differences in cerebellar circuity with general risk for mental illness. Read about the findings at Psychology Today or Duke Today.

A New Home!

January 12, 2017

WilliamsThe LoNG has moved from the Sociology/Psychology building on Duke's West Campus to the Grey Building at 2020 West Main St.

A Williams Syndrome Gene, Extraversion, and the Amygdala

January 5, 2017

Williams This month's issue of Biological Psychiatry features work from the LoNG on a common variant in a Williams Syndrome gene as well as a corresponding editorial piece.

DNS complete!

November 21, 2016

DNScomplete The LoNG scans its final DNS participant, for a total of 1330!

MRI Scans for the Dunedin Longitudinal Study

November 4, 2016

BRHCThe University of Otago in NZ, where the LoNG and colleagues will scan the brains of the 1000 Dunedin Longitudinal Study participants, comments on the launch of the study.

Thinking and Feeling

October 12, 2016

Matt_CPSLoNG graduate student Matt Scult links activity in the prefrontal cortex during computation in working memory with the ability to regulate emotion.

Decoding Emotional States

September 23, 2016

Emotional StatesThe LoNG has collaborated with the LaBar Lab to map spontaneous emotional states in the brain during resting-state fMRI. Read more on Duke Today.

Genotyping Services for Research

July 13, 2016

23andMeReleaseLoNG collaborator 23andMe publicly releases its Genotyping Services for Research. See Dr. Hariri's comments and more at The Verge.

Socioeconomic status, epigenetics, the brain, and depression

May 24, 2016

ses-epigeneticsThe LoNG identifies an epigenetic and brain pathway linking low socioeconomic status to depression, published this month in Molecular Psychiatry.

3D brain printing!

April 29, 2016

3dBrainWith some help from Duke Engineering, the LoNG printed out a 3D model of Professor Hariri's brain from an MRI scan!

23andMe Genotyping Research Service

March 29, 2016

23andMeFor several years, the LoNG has partnered with the consumer genetics firm 23andMe for genotyping study participants. Now the company is slated for a full launch of this service for researchers everywhere. See Dr. Hariri's comments and more at GenomeWeb.

Hot-wired for Happiness?

March 4, 2016

BrainHackingThe Washington Post covers new research on treating depression, mentioning work from the LoNG.

Finding translation in stress research

October 1, 2015

HaririHolmesNNProfessor Hariri co-authors a Nature Neuroscience review with Andrew Holmes discussing translational stress research.

Looking Inside the Disordered Brain

September 23, 2015

APAreviewThe American Psychological Association gives a glowing review of Professor Hariri's textbook, Looking Inside the Disordered Brain.

Fear and reward circuity, stress, and problem drinking

June 30, 2015

YuliyaMPThe LoNG publishes more on how fear and reward circuitry can interact to predict stress-related problem drinking. Click the button below to see the publication, or check out Duke's press release covering this as well as the lab's findings on sexual risk behavior.

Sex and the brain

June 22, 2015

LizVictorAmygdala & ventral striatum reactivity interact to predict gender-specific sexual risk behavior - check out former graduate student Liz Victor's findings!

Congrats!

May 1, 2015

AdrienneNSF

Genetic Me

April 19, 2015

GeneticMeCheck out the the trailer for Genetic Me, a documentary by Danish science journalist Lone Frank, including appareances by Professor Hariri. Release date in the US TBA.

Amygdala reactivity predicts future depressive symptoms

February 4, 2015

JohnnaNeuronCheck out the Huffington Post's coverage of LoNG postdoctoral researcher Johnna Swartz's finding that amygdala reactivity can predict future depressive symptoms, published in the journal Neuron (be sure to watch the video!). See additional coverage of the publication at Men's Health and other outlets.

Family history and stress may interact to influence risk for depression through the amygdala

January 16, 2015

JohnnaAJP LoNG postdoctoral researcher Johnna Swartz recently published in the American Journal of Psychiatry a finding that family history of depression and stressful life events may interact to influence risk for depression by altered development of amygdala reactivity during adolescence.

Duke Neuroscience Program of Research

September 2, 2014

UndergradResearchWatch a video about Duke's summer research program for undergraduate neuroscience majors, including Jacob Miller who worked in the LoNG in the 2014 Summer term.

Novel research in testosterone and threat processing by LoNG alum

September 1, 2014

CarreLoNG alum and collaborator Justin Carre publishes new research on the effects of testosterone on neural reactivity to threat in men. Check out the local news coverage of the story.

Beyond Genotype

August 4, 2014

BeyondGenotypeNature Neuorscience publishes a finding by LoNG postdoctoral researcher Yuliya Nikolova on how DNA methylation predicts the brain's response to threat. Check out Duke's press release of the story or the paper in Nature Neuroscience.

Highly Cited

June 20, 2014

WUNCProfessor Hariri is selected as a Thomson Reuters Highly Cited Researcher!

DNS 1000!

May 30, 2014

DNS1000The Duke Neurogenetics Study celebrates the completion of its 1000th participant!

Neuroscience and the Law

March 10, 2014

WUNCListen to Professor Hariri and other Duke faculty discuss neuroscience and the law on WUNC's "The State of Things" radio program.

Study links gene variation to a darker view of life

October 12, 2013

Darker ViewHead over to the Washington Post to see what Professor Hariri has to say about a recent study published in Psychological Science.

Brains On Trial

Updated September 23, 2013

brainsOnTrialActor & director Alan Alda explores the intersections between neuroscience and the criminal justice system in his two-part PBS series, Brains on Trial. Check out Part 1 and Part 2 of the series, or watch as Professor Hariri and other experts at Duke continue the discussion with Alan and hold a question and answer session on the topic.

Congrats!

April 1, 2013

MattNSF

Modern Marvel

February 27, 2013

MarvelCheck out the article on Professor Hariri and the Duke Neurogenetics Study in the Spring issue of Duke Alumni Magazine!

The LoNG shows that fear and reward circuitry interact to predict problem drinking

November 14, 2012

DrinkingCheck out the press release in the UK, read Discover magazine's blog about it, or listen to the CBS news radio clip.

The LoNG wins the editorial choice award in Duke's Halloween photo contest!

November 7, 2012

DrinkingIn the spirit of the season, we carved a pumpkin and posed it for the three stages of the Duke Neurogenetics Study. It was a hit!

Search for Parkinson's genes turns to online social networking

August 21, 2012

23andMeTake a look at this recent news piece about our scientific collaborator, 23andMe.

The LoNG's Yuliya Nikolova is Awarded the HHMI Fellowship!

July 25, 2012

HHMI

Professor Hariri appears on Radio In Vivo

June 27, 2012

radioinvivoListen to Professor Hariri discuss the Duke Neurogenetics Study on a radio program exploring scientific work in the Research Triangle.

Using cannabinoids to overcome fear in the brain

June 12, 2012

Scientific AmericanCan regulating a specific enzyme help treat anxiety disorders in people? Check out Professor Hariri's comments in the latest issue of Scientific American.

Professor Hariri and the Duke Neurogenetics Study in Discover

April 18, 2012

The
  ScientistCheck out this article in the May 2012 issue of Discover magazine for a glimpse of the Duke Neurogenetics Study and Professor Hariri's work.

Duke Institute for Genome Sciences & Policy's Genome Life

December 2011

The
  ScientistThe Laboratory of NeuroGenetics is featured in the November/December 2011 issue of Duke IGSP's periodical.

Soldiers' Amygdalae Show Scars

August 30, 2011

Soldiers' AmygdalaeProfessor Hariri comments on findings in the amygdalae of Dutch combat soldiers.

Social Science Magazine at Duke Faculty Profile

April 1, 2011

Prefrontal ConnectionGet to know Professor Hariri and the LoNG.

A Marker for PTSD in Women?

February 28, 2011

Prefrontal ConnectionProfessor Hariri comments on a new study on a possible biomarker of risk for PTSD in women.

New Journal: Biology of Mood and Anxiety Disorders

February 15, 2011

Prefrontal ConnectionProfessor Hariri is co-Editor-in-Chief of the new journal Biology of Mood and Anxiety Disorders. Learn more about this exciting new outlet for the best research in the field.

The Amygdala: Inside and Out

February 15, 2011

The Scientist In the latest issue of The Scientist, Professors Hariri and Whalenreview how our evolving understanding of the amygdala will lead to new strategies for treating and predicting psychopathology. In a companion report at F1000 they provide additional details about how different psychological, biological, and genetic factors can influence the sensitivity of the amygdala to give rise to differences in behavior between individuals.

Read the editor's comments
Get to know the authors

Prefrontal Connection May Be Key In Controlling Anxiety

February 14, 2011

Prefrontal ConnectionProfessor Hariri comments on neural correlates of anxiety in an article published by the Dana Foundation.

Spotlight On: Justin Carre

February 4, 2011

Prefrontal ConnectionJustin is included in the 2010 - 2011 Both Sides of the Brain profiles, which highlight his investigation of hormonal involvement in competition, a combination of his dual-passion for neuroscience and hockey.

Loneliness in Science

January 18, 2011

Anxious TimesScience highlights new research, including a study by Professor Hariri & colleagues, suggesting that chronic loneliness can cause changes in the cardiovascular, immune, and nervous systems.

Spotlight on: Patrick Fisher, University of Pittsburgh

December 3, 2010

Anxious TimesPatrick Fisher is highlighted as a scholar of the Blueprint-funded Multimodal Neuroimaging Training Program (MNTP).

Genes & Environment: Finding the Missing Heritability of Complex Traits

October 14 & 15, 2010

Anxious TimesWatch lectures by Professor Hariri and other leading scientists at the Genes & Environment: Finding the Missing Heritability of Complex Traits conference held at Stanford University on October 14 & 15, 2010

An Interplay of Genes and Environment

October 20, 2010

Anxious TimesResearch by partners Terrie Moffitt and Avshalom Caspi have open new means to understand how genes interact with our environment.

Adam Returns from Cambodia!

August 25, 2010

Anxious TimesAdam returns from his worldly travels. He thought that his trip was to Cambodia, but he was surprised to find himself on the set of "Legends of the Hidden Temple." Regardless, he had a good time, and the Nickelodeon network has recruited him as the new host of the hit show. Adam will continue to work in the lab, however he takes his new role very seriously! You just don't mess with the Hidden Temple!

Adam Makes a New, Very Large, Friend
Legends of the Hidden Temple

The Makings of an Anxious Temperament

August 13, 2010

Anxious TimesScienceNow reports on a study published in Nature that used FDG-PET in a large single-family pedigree of rhesus monkeys to estimate the heritability of brain regions shaping the expression of anxious temperament. Professor Hariri provides expert commentary and compares these findings to the LoNG's ongoing imaging genetics research.

Anxious Times

August 10, 2010

Anxious TimesDukeMed Magazine features a story on the challenges of diagnosing, treating, and living with anxiety in modern times. Professor Hariri provides expert commentary and analysis.

Social Disadvantages on the Brain

August 2, 2010

Peter GianarosLoNG collaborator, Dr. Peter Gianaros, is featured in an article reviewing the impact of social disadvantage on the brain.

Just Buy It: Impulsiveness Tied to Brain Chemical

July 30, 2010

brainCurious about why that food dehydrator on late night TV is so tempting? NPR's Morning Edition discusses the influence of dopamine and its receptors on trait impulsivity. This report comes from a new study in Science that links dopamine autoregulation and impulsivity. Listen to Professor Hariri's comments.

A Frightful Genetic Twist

January 14, 2010

Frightful Genetic TwistScienceNOW Daily News discusses new research that points to the potential involvement of the BDNF gene in modulating fear circuitry. Professor Hariri provides expert commentary and analysis.

Revoking Serotonin's Auto License

January, 2010

Frightful Genetic TwistThe Science-Business eXchange discusses the 5HT-1A autoreceptor and current research on its relationship to anxiety and depression. Professor Hariri provides expert commentary and analysis.

Gene-Environment Conference

May 18th-19th, 2009

Reward-Related Ventral Striatal Reactivity Predicts ImpulsivityThe Gene-Environment Conference took place at the Sanford Institute for Public Policy on May 18th and 19th, 2009. View the interesting talks online from Professors Rutter, Moffitt, Caspi, Hariri, and others pertaining to interactions between genes, brains, and behavior.

Neuroscience of Emotion Conference

June 4-6, 2009

Tufts UniversityThe Neuroscience of Emotion Conference took place at Tufts University, June 4-6, 2009.

Wall Street Journal Investigates Investing Personality

Investing Personality in DNAIs Your Investing Personality in Your DNA? Jason Zweig of The Wall Street Journal visits Professor Hariri’s laboratory to find out if his genes and brain activity help to shape his behavior.