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Neuroimaging, especially BOLD fMRI, has begun to identify how variability in brain function contributes to individual differences in complex behavioral traits. In parallel, pharmacological fMRI and multimodal PET/fMRI is identifying how variability in molecular signaling pathways influences individual differences in brain function. Against this background, functional genetic polymorphisms are being utilized to understand the origins of variability in signaling pathways as well as to efficiently model how such emergent variability impacts behaviorally relevant brain function.

The Laboratory of NeuroGenetics (LoNG) at Duke University employs a research strategy seeking to integrate these complimentary technologies in the service of illuminating the neurobiology of individual differences in complex behavioral traits. The LoNG works with collaborators both at Duke and abroad to translate these efforts into the establishment of predictive risk markers that may interact with unique environmental factors to precipitate psychopathology and also lead to the development of individually tailored treatment.

For a list of current collaborative projects and instructions on submitting a new data sharing proposal, please see our Data Sharing page.